• 30-day mortality in patients treated for brain metastases: extracranial causes dominate 

      Nieder, Carsten; Stanisavljevic, Luka; Aanes, Siv Gyda; Mannsåker, Bård; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-12)
      Background: Established prognostic models, such as the diagnosis-specific graded prognostic assessment, were not designed to specifically address very short survival. Therefore, a brain metastases-specific 30-day mortality model may be relevant. We hypothesized that in-depth evaluation of a carefully defined cohort with short survival, arbitrarily defined as a maximum of 3 months, may provide ...
    • Early death after palliative radiation treatment: 30-, 35- and 40-day mortality data and statistically robust predictors 

      Nieder, Carsten; Stanisavljevic, Luka; Mannsåker, Bård; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-03)
      Background This study analyzed mortality after radiotherapy for bone metastases (287 courses). Endpoints such as treatment in the last month of life and death within 30, 35 and 40 days from start of radiotherapy were evaluated.<p> <p>Methods Different baseline parameters including but not limited to blood test results and patterns of metastases were assessed for association with early death. After ...
    • Feasibility and efficacy of early docetaxel plus androgen deprivation therapy for metastatic hormone-sensitive prostate cancer in a rural health care setting 

      Nieder, Carsten; Stanisavljevic, Luka; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-17)
      Aim/Background - The aim of this study was to evaluate the feasibility and efficacy, in terms of overall survival, of intensified upfront systemic therapy in patients with metastatic hormone-sensitive prostate cancer who lived in rural Nordland County, Norway.<p> <p>Patients and methods - Overall 117 patients were included in this retrospective study. Three cohorts were created: early docetaxel ...
    • Independent validation of a risk stratification model predicting survival in elderly patients irradiated for bone metastases 

      Nieder, Carsten; Stanisavljevic, Luka; Mannsåker, Bård; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02)
      Background/Aim: Many patients with bone metastases receive palliative radiotherapy. However, treatment personalization tools are needed, due to heterogeneous survival. The aim of this study was to analyze the validity of the prognostic survival model, originally developed by Rades et al., because international variations in clinical practice and survival outcomes may impact on the performance of ...
    • Independent Validation of a Risk Stratification Model Predicting Survival in Patients With Metastatic Hormone-sensitive Prostate Cancer 

      Nieder, Carsten; Stanisavljevic, Luka (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-05)
      Background/Aim: The aim of this study was to analyze the survival predictions obtained from an online nomogram, originally developed in two US patient cohorts with metastatic hormone-sensitive prostate cancer, because clinical practice and survival outcomes may vary on an international level. Patients and Methods: A retrospective single-institution study of 197 patients, managed according to Norwegian ...
    • Independent Validation of a Unifying Prognostic Model for Intracranial and Extracranial Metastasis-directed Radiotherapy 

      Nieder, Carsten; Stanisavljevic, Luka; Mannsåker, Bård; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-06)
      We present the first calculations of the heavy flavor diffusion coefficient using lattice QCD with light dynamical quarks corresponding to a pion mass of around 320 MeV. For temperatures 195 MeV <T< 352 MeV, the heavy quark spatial diffusion coefficient is found to be significantly smaller than previous quenched lattice QCD and recent phenomenological estimates. The result implies very fast ...
    • Patterns of Care and Survival in Cancer Patients with Brain Metastases Receiving Immune Checkpoint Inhibitors 

      Nieder, Carsten; Mannsåker, Bård; Stanisavljevic, Luka; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-15)
      Introduction: Immune checkpoint inhibitors (ICIs) have become a mainstay of treatment for different cancer types. The purpose of this study was to evaluate patterns of care and overall survival (OS) after diagnosis of brain metastases in patients managed with ICI as component of care. Methods: This was a retrospective cohort study. Fifty patients were included (34 with brain metastases at first ...